The hippocampus is one of the oldest regions of the brain (the archicortex), and has wide-reaching connections. Our findings extend the collective knowledge of hippocampal anatomy, highlighting the importance of the spinal-limbic pathway and the striking lack of hippocampal connectivity with motor and sensory cortices. Overall, our results concur with preclinical and ex-vivo data, confirming that meaningful in vivo characterisation of hippocampal connections is possible in an individual. There was a strong age dependence of hippocampal connectivity to medial occipital regions. The strongest individual connection was to the ipsilateral thalamus. Using a connectomic approach, we identified six dominant pathways in terms of strength, length and anatomy, and characterised them by their age and gender variation. We tracked the whole-brain connections of white matter fibres from the hippocampus using ultra-high angular resolution diffusion MRI in both a single 1150-direction dataset and a large normal cohort (nā=ā94 391-directions). The hippocampus is a key component of emotional and memory circuits and is broadly connected throughout the brain.
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